abstract：RATIONALE:Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES:To identify prognostic factors of good neurologic outcome in patients admitted to an ...

journal_title：American journal of respiratory and critical care medicine

authors： de Montmollin E,Demeret S,Brulé N,Conrad M,Dailler F,Lerolle N,Navellou JC,Schwebel C,Alves M,Cour M,Engrand N,Tonnelier JM,Maury E,Ruckly S,Picard G,Rogemond V,Magalhaes É,Sharshar T,Timsit JF,Honnorat J,Sonnevil

更新日期：2017-02-15 00:00:00

abstract：RATIONALE:In the absence of a surgical lung biopsy, patients diagnosed with idiopathic pulmonary fibrosis (IPF) in clinical practice could participate in the INPULSIS trials of nintedanib if they had honeycombing and/or traction bronchiectasis plus reticulation, without atypical features of usual interstitial pneumonia...

journal_title：American journal of respiratory and critical care medicine

authors： Raghu G,Wells AU,Nicholson AG,Richeldi L,Flaherty KR,Le Maulf F,Stowasser S,Schlenker-Herceg R,Hansell DM

更新日期：2017-01-01 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:Typical for critical illnesses are substantial alterations within the hypothalamic-anterior pituitary-peripheral hormonal axes that are proportionate to the risk of poor outcome. These neuroendocrine responses to critical illness follow a biphasic pattern. The acute phase (first hours to days) is characterized by an i...

journal_title：American journal of respiratory and critical care medicine

authors： Van den Berghe G

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Tumor-infiltrating immune cells affect lung cancer outcome. However, the factors that influence the composition and function of the tumor immune environment remain poorly defined and need investigation, particularly in the era of immunotherapy. OBJECTIVES:To determine whether the tumoral immune environment i...

journal_title：American journal of respiratory and critical care medicine

authors： Mansuet-Lupo A,Alifano M,Pécuchet N,Biton J,Becht E,Goc J,Germain C,Ouakrim H,Régnard JF,Cremer I,Laurent-Puig P,Dieu-Nosjean MC,Blons H,Damotte D

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease (ILD) characterized by abnormal extracellular matrix (ECM) remodeling. We hypothesized that ECM remodeling might result in a plasma profile of proteins specific for IPF that could distinguish patients with IPF from other idi...

journal_title：American journal of respiratory and critical care medicine

authors： White ES,Xia M,Murray S,Dyal R,Flaherty CM,Flaherty KR,Moore BB,Cheng L,Doyle TJ,Villalba J,Dellaripa PF,Rosas IO,Kurtis JD,Martinez FJ

更新日期：2016-11-15 00:00:00

abstract：RATIONALE:In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal glucose tolerance may begin in early life. OBJECTIVES:To determine whether very young children with cystic fibrosis have increased abnormal glucose t...

journal_title：American journal of respiratory and critical care medicine

authors： Yi Y,Norris AW,Wang K,Sun X,Uc A,Moran A,Engelhardt JF,Ode KL

更新日期：2016-10-15 00:00:00

abstract：RATIONALE:Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES:To examine the functional and transcriptional profiles of pa...

journal_title：American journal of respiratory and critical care medicine

authors： Juss JK,House D,Amour A,Begg M,Herre J,Storisteanu DM,Hoenderdos K,Bradley G,Lennon M,Summers C,Hessel EM,Condliffe A,Chilvers ER

更新日期：2016-10-15 00:00:00

abstract：RATIONALE:Infection with Pneumocystis, an opportunistic fungal pathogen, can result in fulminant pneumonia in the clinical setting of patients with immunosuppression. In murine models, Pneumocystis has previously been shown to induce a CD4+ T cell-dependent eosinophilic response in the lung capable of providing protect...

journal_title：American journal of respiratory and critical care medicine

authors： Eddens T,Campfield BT,Serody K,Manni ML,Horne W,Elsegeiny W,McHugh KJ,Pociask D,Chen K,Zheng M,Alcorn JF,Wenzel S,Kolls JK

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES:To describe the incidence, characteristics, and impact of ...

journal_title：American journal of respiratory and critical care medicine

authors： Tikkanen JM,Singer LG,Kim SJ,Li Y,Binnie M,Chaparro C,Chow CW,Martinu T,Azad S,Keshavjee S,Tinckam K

更新日期：2016-09-01 00:00:00

abstract：:Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury. However, identification of crucial signaling and execution molec...

journal_title：American journal of respiratory and critical care medicine

authors： Moreno-Gonzalez G,Vandenabeele P,Krysko DV

更新日期：2016-08-15 00:00:00

abstract：RATIONALE:Pulmonary complications (PCs) cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HCT). Shifts in gut microbiota have been linked to HCT outcomes; however, their effect on PCs is unknown. OBJECTIVES:To investigate whether changes in gut microbiota are associate...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Morjaria SM,Littmann ER,Geyer AI,Stover DE,Barker JN,Giralt SA,Taur Y,Pamer EG

更新日期：2016-08-15 00:00:00

abstract：RATIONALE:The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms that determine the outcome of infection with Mycobacterium tuberculosis. OBJECTIVES:To identify T-cell-dependent mechanisms that are protective in tuberc...

journal_title：American journal of respiratory and critical care medicine

authors： Busch M,Herzmann C,Kallert S,Zimmermann A,Höfer C,Mayer D,Zenk SF,Muche R,Lange C,Bloom BR,Modlin RL,Stenger S,TBornotTB Network.

更新日期：2016-08-01 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic...

journal_title：American journal of respiratory and critical care medicine

authors： Collard HR,Ryerson CJ,Corte TJ,Jenkins G,Kondoh Y,Lederer DJ,Lee JS,Maher TM,Wells AU,Antoniou KM,Behr J,Brown KK,Cottin V,Flaherty KR,Fukuoka J,Hansell DM,Johkoh T,Kaminski N,Kim DS,Kolb M,Lynch DA,Myers JL,R

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Noncommunicable diseases are major causes of morbidity and mortality in sub-Saharan Africa (sSA). Valid burden of disease estimates are lacking for noncommunicable lung disease in sSA. OBJECTIVES:We performed a community-based survey to determine the prevalence of chronic lung disease among adults 18 years o...

journal_title：American journal of respiratory and critical care medicine

authors： Meghji J,Nadeau G,Davis KJ,Wang D,Nyirenda MJ,Gordon SB,Mortimer K

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. OBJECTIVES:To investigate the impact of cell death signals at 24 and 48 hours after lung transplantation on short...

journal_title：American journal of respiratory and critical care medicine

authors： Hashimoto K,Besla R,Zamel R,Juvet S,Kim H,Azad S,Waddell TK,Cypel M,Liu M,Keshavjee S

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction (emphysema), whose relative proportion varies from patient to patient. OBJECTIVES:To explore and contrast the molecular pathogenes...

journal_title：American journal of respiratory and critical care medicine

authors： Faner R,Cruz T,Casserras T,López-Giraldo A,Noell G,Coca I,Tal-Singer R,Miller B,Rodriguez-Roisin R,Spira A,Kalko SG,Agustí A

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain. OBJECTIVES:The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neuro...

journal_title：American journal of respiratory and critical care medicine

authors： Chowdhuri S,Quan SF,Almeida F,Ayappa I,Batool-Anwar S,Budhiraja R,Cruse PE,Drager LF,Griss B,Marshall N,Patel SR,Patil S,Knight SL,Rowley JA,Slyman A,ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea.

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s. OBJECTIVES:To assess traffic-related pollution exposure and childhood lung function. METHODS:We geocoded addresses for 614 mother-child pa...

journal_title：American journal of respiratory and critical care medicine

authors： Rice MB,Rifas-Shiman SL,Litonjua AA,Oken E,Gillman MW,Kloog I,Luttmann-Gibson H,Zanobetti A,Coull BA,Schwartz J,Koutrakis P,Mittleman MA,Gold DR

更新日期：2016-04-15 00:00:00

abstract：RATIONALE:Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES:To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. ...

journal_title：American journal of respiratory and critical care medicine

authors： May AM,Blackwell T,Stone PH,Stone KL,Cawthon PM,Sauer WH,Varosy PD,Redline S,Mehra R,MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study Group.

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:The use of high-frequency oscillatory ventilation (HFOV) for acute respiratory failure in children is prevalent despite the lack of efficacy data. OBJECTIVES:To compare the outcomes of patients with acute respiratory failure managed with HFOV within 24-48 hours of endotracheal intubation with those receiving...

journal_title：American journal of respiratory and critical care medicine

authors： Bateman ST,Borasino S,Asaro LA,Cheifetz IM,Diane S,Wypij D,Curley MA,RESTORE Study Investigators.

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:As of April 2015, participants in the Danish Lung Cancer Screening Trial had been followed for at least 5 years since their last screening. OBJECTIVES:Mortality, causes of death, and lung cancer findings are reported to explore the effect of computed tomography (CT) screening. METHODS:A total of 4,104 parti...

journal_title：American journal of respiratory and critical care medicine

authors： Wille MM,Dirksen A,Ashraf H,Saghir Z,Bach KS,Brodersen J,Clementsen PF,Hansen H,Larsen KR,Mortensen J,Rasmussen JF,Seersholm N,Skov BG,Thomsen LH,Tønnesen P,Pedersen JH

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely specula...

journal_title：American journal of respiratory and critical care medicine

authors： Tabuchi A,Nickles HT,Kim M,Semple JW,Koch E,Brochard L,Slutsky AS,Pries AR,Kuebler WM

更新日期：2016-02-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：RATIONALE:Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. OBJECTIVES:To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically rele...

journal_title：American journal of respiratory and critical care medicine

authors： James AJ,Reinius LE,Verhoek M,Gomes A,Kupczyk M,Hammar U,Ono J,Ohta S,Izuhara K,Bel E,Kere J,Söderhäll C,Dahlén B,Boot RG,Dahlén SE,BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway

更新日期：2016-01-15 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：:Guidelines, protocols, and checklists (together called "protocols") can be immensely helpful in the clinical arena. However, clinicians and health care systems relying on protocols must assess whether benefits are being accrued, whether such "benefits" are real, and whether harm can be detected. These concerns are imp...

journal_title：American journal of respiratory and critical care medicine

authors： Kavanagh BP,Nurok M

更新日期：2016-01-01 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：RATIONALE:The mechanism by which acute allograft rejection leads to chronic rejection remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect the biologic state of the cell and tissue...

journal_title：American journal of respiratory and critical care medicine

authors： Gregson AL,Hoji A,Injean P,Poynter ST,Briones C,Palchevskiy V,Weigt SS,Shino MY,Derhovanessian A,Sayah D,Saggar R,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2015-12-15 00:00:00

abstract：RATIONALE:Dysregulation of cellular metabolism has been shown to participate in several pathologic processes. However, the role of metabolic reprogramming is not well appreciated in the pathogenesis of organ fibrosis. OBJECTIVES:To determine if glycolytic reprogramming participates in the pathogenesis of lung fibrosis...

journal_title：American journal of respiratory and critical care medicine

authors： Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G

更新日期：2015-12-15 00:00:00

abstract：:Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the N...

journal_title：American journal of respiratory and critical care medicine

authors： Levy BD,Noel PJ,Freemer MM,Cloutier MM,Georas SN,Jarjour NN,Ober C,Woodruff PG,Barnes KC,Bender BG,Camargo CA Jr,Chupp GL,Denlinger LC,Fahy JV,Fitzpatrick AM,Fuhlbrigge A,Gaston BM,Hartert TV,Kolls JK,Lynch SV,Moo

更新日期：2015-12-01 00:00:00

abstract：RATIONALE:Improved understanding of the lung microbiome in HIV-infected individuals could lead to better strategies for diagnosis, therapy, and prophylaxis of HIV-associated pneumonias. Differences in the oral and lung microbiomes in HIV-infected and HIV-uninfected individuals are not well defined. Whether highly activ...

journal_title：American journal of respiratory and critical care medicine

authors： Beck JM,Schloss PD,Venkataraman A,Twigg H 3rd,Jablonski KA,Bushman FD,Campbell TB,Charlson ES,Collman RG,Crothers K,Curtis JL,Drews KL,Flores SC,Fontenot AP,Foulkes MA,Frank I,Ghedin E,Huang L,Lynch SV,Morris A,Pa

更新日期：2015-12-01 00:00:00

abstract：RATIONALE:Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. OBJECTIVES:To describe the evolution of diaphragm th...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Fan E,Herridge MS,Murray A,Vorona S,Brace D,Rittayamai N,Lanys A,Tomlinson G,Singh JM,Bolz SS,Rubenfeld GD,Kavanagh BP,Brochard LJ,Ferguson ND

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating acetyl-proline-glycine-proline (AcPGP) p...

journal_title：American journal of respiratory and critical care medicine

authors： Wells JM,Jackson PL,Viera L,Bhatt SP,Gautney J,Handley G,King RW,Xu X,Gaggar A,Bailey WC,Dransfield MT,Blalock JE

更新日期：2015-10-15 00:00:00

abstract：RATIONALE:Community-acquired pneumonia (CAP) accounts for a major proportion of intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic uncertainty complicates case management, which may delay appropriate cause-specific treatment. OBJECTIVES:To characterize the blood genomic response in pat...

journal_title：American journal of respiratory and critical care medicine

authors： Scicluna BP,Klein Klouwenberg PM,van Vught LA,Wiewel MA,Ong DS,Zwinderman AH,Franitza M,Toliat MR,Nürnberg P,Hoogendijk AJ,Horn J,Cremer OL,Schultz MJ,Bonten MJ,van der Poll T

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia vaccines are slow and costly, requiring tens of thousands of patients. Studies of pneumococcal vaccine efficacy against colonization have been proposed as a novel method to down-select between vac...

journal_title：American journal of respiratory and critical care medicine

authors： Collins AM,Wright AD,Mitsi E,Gritzfeld JF,Hancock CA,Pennington SH,Wang D,Morton B,Ferreira DM,Gordon SB

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00